Jabwise

Feeling tired on a GLP-1

All four list it, and both NHS pages name feeling tired among common side effects. Wegovy’s leaflet calls feeling weak or tired very common, and says it usually goes away over time; Ozempic’s calls tiredness common. In two Zepbound trials, 5% to 7% reported fatigue, against 3% on placebo.

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The Energy slider in a Jabwise check-in

How common it is

From each leaflet and Zepbound’s label, quoted as written. Mounjaro’s gives a different answer for its heart study of people with type 2 diabetes.

MedicineListed asHow common
MounjaroFeeling tired (fatigue)Mounjaro KwikPen patient leafletFatigue was very common in the type 2 diabetes cardiovascular disease study and common in patients treated for weight management, and type 2 diabetes.Mounjaro KwikPen patient leaflet
Zepboundfeeling tiredZepbound prescribing informationThe most common adverse reactions, reported in ≥5% of patients treated with ZEPBOUNDZepbound prescribing information
Wegovyfeeling weak or tiredWegovy FlexTouch patient leafletVery common: may affect more than 1 in 10 peopleWegovy FlexTouch patient leaflet
OzempicTirednessOzempic patient leafletCommon (may affect up to 1 in 10 people)Ozempic patient leaflet

What else they say

  • It often eases

    Wegovy’s leaflet lists feeling weak or tired with its very common side effects, and says these usually go away over time.

  • In Zepbound’s trials

    Fatigue, counting weakness and lethargy, was reported by 5% to 7% of people on Zepbound, against 3% on placebo.

  • Low blood sugar signs

    Mounjaro’s leaflet lists drowsiness and weakness among signs of low blood sugar, likelier with insulin or a sulphonylurea.

  • If it bothers you

    If a side effect bothers you or doesn’t go away, the NHS says a pharmacist or doctor may give advice on how to reduce it.

Questions

Does Mounjaro make you tired?

Its leaflet lists feeling tired (fatigue): very common in a heart study of people with type 2 diabetes, and common in people treated for weight management or type 2 diabetes.

Does the tiredness go away?

Wegovy’s leaflet says its very common side effects, feeling weak or tired among them, usually go away over time. The other leaflets don’t say so for tiredness.

Could it be low blood sugar?

Mounjaro’s leaflet lists drowsiness and weakness among the symptoms of low blood sugar, and Wegovy’s lists feeling sleepy or weak, for people with diabetes. Mounjaro’s says your doctor should tell you how to treat it.

Check-ins

Jabwise notes your energy through the day.

Mood, food noise and energy on three sliders, morning, afternoon and evening, then a tap for any side effects. Progress shows how each changes over time.

Jabwise morning check-in with sliders for mood, food noise and energy

Sources

General information, not medical advice. Follow your prescriber’s guidance.

Getting real advice

We’re not doctors. This page sums up what the NHS and the official medicine information say, and can’t tell you what’s right for your body: your prescriber’s instructions and the leaflet in your box come first. More in our terms.

  • Quoted from official sources, each one linked
  • Sources checked 12 October 2026
  • No dosing advice; your prescriber comes first