How the doses step up
Slowly, each starting on a low dose for 4 weeks. Mounjaro and Zepbound start at 2.5mg a week for 4 weeks, then 5mg, and may go up in 2.5mg steps, at least 4 weeks on each, to as much as 15mg. Wegovy starts at 0.25mg and rises every 4 weeks to 2.4mg from week 17. Your prescriber decides each step.
In their own words
Each leaflet’s start and the steps after it, quoted as written.
| Medicine | Starts on | Then |
|---|---|---|
| Mounjaro | The starting dose is 2.5 mg once a week for four weeks.Mounjaro KwikPen patient leaflet | After four weeks your doctor will increase your dose to 5 mg once a week.Mounjaro KwikPen patient leaflet |
| Zepbound | The recommended starting dosage is 2.5 mg injected subcutaneously once weekly for 4 weeks.Zepbound prescribing information | Increase the dosage in 2.5 mg increments after at least 4 weeks until recommended maintenance dosage is achieved.Zepbound prescribing information |
| Wegovy | When you first start using wegovy®, the starting dose is 0.25 mg once weekly.Wegovy FlexTouch patient leaflet | Your doctor will instruct you to gradually increase your dose every 4 weeks until you reach the dose of 2.4 mg once weekly.Wegovy FlexTouch patient leaflet |
| Ozempic | The starting dose is 0.25 mg once a week for four weeks.Ozempic patient leaflet | After four weeks your doctor will increase your dose to 0.5 mg once a week.Ozempic patient leaflet |
Wegovy, week by week
The table in Wegovy’s leaflet for weight management. 7.2mg is for adults with obesity, if needed, and is three 2.4mg injections on the same day.
| Weeks | Weekly dose |
|---|---|
| Weeks 1 to 4 | 0.25mg |
| Weeks 5 to 8 | 0.5mg |
| Weeks 9 to 12 | 1mg |
| Weeks 13 to 16 | 1.7mg |
| From week 17 | 2.4mg |
| From week 21 | 7.2mg, if needed |
Worth knowing
At least 4 weeks a step
Mounjaro’s leaflet and Zepbound’s label both say at least 4 weeks on one dose before moving to a higher one.
Not every step
Your doctor may go higher if needed, Mounjaro’s says. Zepbound’s weight maintenance doses: 5, 10 or 15mg.
Your doctor’s call
Mounjaro’s and Ozempic’s leaflets say not to change your dose unless your doctor has told you to do so.
Questions
Do I have to go up to the top dose?
Mounjaro’s leaflet says your doctor may increase your dose if you need it, and Zepbound’s label lists 5mg, 10mg or 15mg as maintenance doses for weight reduction. Wegovy’s leaflet steps up to 2.4mg, with 7.2mg only if needed. Your prescriber decides.
Can I go up faster?
Mounjaro and Zepbound say at least 4 weeks on each dose, and Wegovy steps up every 4 weeks. Mounjaro’s and Ozempic’s leaflets say not to change your dose unless your doctor has told you to do so.
What is Wegovy 7.2mg?
A higher dose in Wegovy’s leaflet for adults with obesity, if needed, after at least 4 weeks on 2.4mg. The leaflet says it is three 2.4mg injections, one after another on the same day.
How does Ozempic step up?
From 0.25mg for four weeks to 0.5mg. Its leaflet says your doctor may go to 1mg, then 2mg, if your blood sugar is not controlled well enough on the dose before.
Progress by dose
Jabwise draws your weight across every dose.
Record each new strength and the day you started it. The chart on Progress shades every dose as its own band and runs your weigh-ins across them, since treatment began.

Sources
- Mounjaro KwikPen patient leaflet
- Zepbound prescribing information
- Wegovy FlexTouch patient leaflet
- Ozempic patient leaflet
General information, not medical advice. Follow your prescriber’s guidance.
Getting real advice
We’re not doctors. This page sums up what the NHS and the official medicine information say, and can’t tell you what’s right for your body: your prescriber’s instructions and the leaflet in your box come first. More in our terms.
- Quoted from official sources, each one linked
- Sources checked 12 October 2026
- No dosing advice; your prescriber comes first
- A pharmacist, your doctor or NHS 111If you’re not sure how to use your medicine, or a side effect bothers you or won’t go away. NHS 111 if you think you might be having serious side effects, or you’ve used too much.NHS: SemaglutideNHS: TirzepatideNHS 111 online
- Report a side effectAnyone can, not only doctors.Yellow Card (UK)MedWatch (US)