Taking it with other medicines
Tell your doctor, pharmacist or nurse about other medicines, Mounjaro’s, Wegovy’s and Ozempic’s leaflets say. The NHS names warfarin, insulin, other diabetes medicines and, for semaglutide, levothyroxine. Wegovy’s and Ozempic’s add that warfarin may mean more blood tests, and Zepbound’s that it may affect tablets.
Some of the medicines the sources name
Medicines they name
Each in the words of a source that names it, quoted as written. None of these lists is complete, and the sources ask you to mention any other medicines you take.
| Medicine | What they say |
|---|---|
| Warfarin | Warfarin or other similar medicines taken by mouth to reduce blood clotting (oral anti-coagulants). You may need frequent blood tests to check how quickly your blood clots.Ozempic patient leaflet |
| Insulin | insulin – your doctor or specialist nurse may need to adjust your doseNHS: Tirzepatide |
| Diabetes medicines | other diabetes medicines, such as gliclazide, glimepiride, metformin and tolbutamideNHS: Tirzepatide |
| Levothyroxine | levothyroxine, for an underactive thyroidNHS: Semaglutide |
| The pill | Birth control pills by mouth may not work as well while using ZEPBOUND.Zepbound prescribing information |
| Other tablets | ZEPBOUND delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications.Zepbound prescribing information |
What they ask
Everything you take
Ozempic’s leaflet includes herbal medicines and ones bought without a prescription; the NHS adds vitamins and supplements.
On insulin
Ozempic’s leaflet says your doctor will tell you how to reduce the dose, and recommend checking your blood sugar more often.
Contraception
The NHS says use extra barrier contraception, like condoms, for 4 weeks after starting tirzepatide and each increase.
Rybelsus tablets
Both Rybelsus leaflets say wait at least 30 minutes after it before eating, drinking or taking other oral medicines.
Questions
Can I take it with metformin?
The NHS names metformin among other diabetes medicines that may not mix well with tirzepatide or semaglutide. The NHS says tell your doctor or a pharmacist before you use it.
Does Mounjaro affect the pill?
Mounjaro’s leaflet says women with obesity or overweight on oral contraceptives should consider also using a barrier method, or switching to a non-oral one, for 4 weeks after starting and after each increase.
Who should I tell?
Your doctor, pharmacist or nurse, say the Mounjaro, Wegovy and Ozempic leaflets (Rybelsus’s: doctor or pharmacist), about any medicine you use, have recently used or might use.
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Sources
- Mounjaro KwikPen patient leaflet
- Wegovy FlexTouch patient leaflet
- Ozempic patient leaflet
- Zepbound prescribing information
- Rybelsus 3, 7 and 14mg patient leaflet
- Rybelsus 1.5, 4 and 9mg patient leaflet
- NHS: Semaglutide
- NHS: Tirzepatide
General information, not medical advice. Follow your prescriber’s guidance.
Getting real advice
We’re not doctors. This page sums up what the NHS and the official medicine information say, and can’t tell you what’s right for your body: your prescriber’s instructions and the leaflet in your box come first. More in our terms.
- Quoted from official sources, each one linked
- Sources checked 12 October 2026
- No dosing advice; your prescriber comes first
- A pharmacist, your doctor or NHS 111If you’re not sure how to use your medicine, or a side effect bothers you or won’t go away. NHS 111 if you think you might be having serious side effects, or you’ve used too much.NHS: SemaglutideNHS: TirzepatideNHS 111 online
- Report a side effectAnyone can, not only doctors.Yellow Card (UK)MedWatch (US)