Jabwise

Gallstones and the gallbladder

Wegovy’s and Ozempic’s leaflets list gallstones as common, up to 1 in 10, and Mounjaro’s says they were common when used for weight management. The NHS tirzepatide page lists gallstones or a swollen gallbladder as serious. Zepbound’s label says gallbladder events in its trials were associated with weight reduction.

Signs Zepbound’s label listsPain in your upper stomachFeverYellowing of skin or eyesClay-colored stools

How common it is

Each leaflet’s own words for how common gallstones are, quoted as written. Zepbound’s figure is the share of people in its two weight trials.

MedicineHow common
MounjaroIncreased gallstones were common in the cardiovascular disease study and when used for weight management but uncommon when used in adults for type 2 diabetes.Mounjaro KwikPen patient leaflet
Zepbound1.1%, against 1% on placebo
WegovyCommon: may affect up to 1 in 10 peopleWegovy FlexTouch patient leaflet
OzempicCommon (may affect up to 1 in 10 people)Ozempic patient leaflet

What else they say

  • Linked to weight loss

    Zepbound’s label says acute gallbladder events in its two weight trials were associated with weight reduction.

  • A swollen gallbladder

    In those trials, cholecystitis (swelling of the gallbladder) was reported by 0.7% on Zepbound, against 0.2% on placebo.

  • The NHS on tirzepatide

    The NHS tirzepatide page lists gallstones or swelling of the gallbladder, which can cause severe tummy pain, as serious.

  • Gallbladder signs

    Zepbound’s label lists signs to tell your provider about: upper stomach pain, fever, yellow skin or eyes, clay-colored stools.

Questions

Can Mounjaro cause gallstones?

Mounjaro’s leaflet says gallstones were common when it was used for weight management, up to 1 in 10 people, and uncommon in adults treated for type 2 diabetes.

Does Wegovy cause gallstones?

Wegovy’s and Ozempic’s leaflets both list gallstones as common, up to 1 in 10 people. The NHS semaglutide page doesn’t list them.

What does the NHS say?

The NHS tirzepatide page lists gallstones or swelling of the gallbladder among serious side effects, and says call 111 if you think you’re having one.

Progress by dose

Your weight, drawn across each dose.

Record each new strength and the day you started it. Progress shades every dose as its own band and runs your weigh-ins across them, so you can see what each dose did.

Jabwise Progress: 6.8kg lost over 12 weeks, the weight line drawn across the 2.5mg, 5mg, 7.5mg and 10mg dose bands

Sources

General information, not medical advice. Follow your prescriber’s guidance.

Getting real advice

We’re not doctors. This page sums up what the NHS and the official medicine information say, and can’t tell you what’s right for your body: your prescriber’s instructions and the leaflet in your box come first. More in our terms.

  • Quoted from official sources, each one linked
  • Sources checked 12 October 2026
  • No dosing advice; your prescriber comes first